jak2-v617f mutation combined with philadelphia chromosome-positive chronic myeloid leukaemia: a case report

نویسندگان

mehrdad payande medical biology research center, kermanshah university of medical sciences, kermanshah, iran

mohammad erfan zare medical biology research center, kermanshah university of medical sciences, kermanshah, iran; student

saber ghanbari haji shure student of medical lab sciences in research committee, kermanshah university of medical sciences, kermanshah, iran

farhad shaveisi zadeh medical genetics department, faculty of medicine, shahid beheshti university of medical sciences and

چکیده

myeloproliferative neoplasms (mpns) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients. philadelphia chromosome is a sure way to definitively diagnose cml. recently, jak2v617f mutation introduced as a diagnostic marker for other myeloproliferative neoplasms. many studies show that the absence of the jak2 mutation in chronic phase philadelphia positive cml. in contrast with these reports, more recently, several cases with the coexistence of philadelphia positive chromosome and jak2v617f mutation in blood and bone marrow samples were reported. here, we report a patient that have the philadelphia chromosome disorder and jak2v617f mutation in same time.

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JAK2-V617F mutation in a patient with Philadelphia-chromosome-positive chronic myeloid leukaemia.

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jak2-v617f mutation and philadelphia positive chronic myeloid leukemia

jak2 is a tyrosine kinase that plays an important role in the signaling pathways of many hematopoietic growth factor receptors. a single acquired point mutation – v617f – in jak2 occurs in the great majority of patients with polycythemia vera (pv) and approximately half of the patients with idiopathic myelofibrosis (imf) or essential thrombocythemia (et). in contrast, the jak2-v617f mutation is...

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JAK2-V617F mutation and Philadelphia positive chronic myeloid leukemia.

JAK2 is a tyrosine kinase that plays an important role in the signaling pathways of many hematopoietic growth factor receptors. A single acquired point mutation – V617F – in JAK2 occurs in the great majority of patients with polycythemia vera (PV) and approximately half of the patients with idiopathic myelofibrosis (IMF) or essential thrombocythemia (ET). In contrast, the JAK2-V617F mutation is...

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Frequency of JAK2 V617F mutation in patients with Philadelphia positive Chronic Myeloid Leukemia in Pakistan

BACKGROUND AND OBJECTIVE Co-existence of myeloproliferative disorders (MPD) and Janus associated kinase 2 mutation (JAK2 V617F) is a well-established fact. Only few case reports are available showing presence of JAK2 V617F mutation in chronic myeloid leukemia (CML). Purpose of this study was to determine the frequency of JAK2 V617F mutation in Philadelphia Chromosome positive (Ph (+)) CML patie...

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عنوان ژورنال:
international journal of hematology-oncology and stem cell research

جلد ۵، شماره ۲، صفحات ۳۴-۳۷

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